UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses
Summary: Colorectal cancer (CRC) is associated with metabolic and redox perturbation.The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mechanism eyevan 163 in tumors in vivo remains unexplored.Using murine intestinal cancer models and CRC