UCP2 DEFICIENCY INCREASES COLON TUMORIGENESIS BY PROMOTING LIPID SYNTHESIS AND DEPLETING NADPH FOR ANTIOXIDANT DEFENSES

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

Summary: Colorectal cancer (CRC) is associated with metabolic and redox perturbation.The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mechanism eyevan 163 in tumors in vivo remains unexplored.Using murine intestinal cancer models and CRC

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Fate of false vacua in holographic first-order phase transitions

Abstract Using the holographic correspondence as a tool, we study the dynamics of first-order phase transitions in strongly coupled gauge theories at finite temperature.Considering an evolution from the large to the small temperature phase, we compute the nucleation rate of house of lashes blessings bubbles of true vacuum in the metastable phase.Fo

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Estimating Limit Reference Points for Western Pacific Leatherback Turtles (Dermochelys coriacea) in the U.S. West Coast EEZ.

Biological limit reference points (LRPs) for fisheries catch represent upper bounds that avoid undesirable population states.LRPs can support consistent management evaluation among species and regions, and can advance ecosystem-based fisheries management.For transboundary species, LRPs prorated by local abundance can inform local management decisio

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